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Comparison Guide

PRP vs Cortisone Injections

Compare PRP and cortisone injections for sports injuries — cost, effectiveness, recovery time, and which is right for your condition.

How They Work

Cortisone: A powerful anti-inflammatory that quickly reduces swelling and pain. Does not heal tissue — suppresses the inflammatory response. Effects are temporary. Repeated injections can weaken tendons and cartilage.

PRP: Concentrated platelets from your own blood deliver growth factors that stimulate tissue healing. Promotes controlled inflammation. Takes longer to work (2-6 weeks) but aims to address underlying tissue damage.

Cost Comparison

FactorCortisonePRP
Cost per injection$100–$300 (with insurance)$500–$2,000 (cash pay)
Insurance coverageYes (most plans)Rarely covered
Sessions needed1-3 per year (max)1-3 total
Annual cost$100–$900$500–$6,000

Effectiveness by Condition

Tendon injuries: PRP is superior long-term. Cortisone provides faster initial relief but worse outcomes at 6-12 months.

Knee osteoarthritis: Both provide relief. PRP shows better outcomes at 6-12 months in moderate arthritis.

Bursitis and acute inflammation: Cortisone is the clear winner for rapid relief.

Which Should You Choose?

Choose cortisone when: You need fast relief, have acute bursitis, or this is your first injection for the condition.

Choose PRP when: You have a chronic tendon injury, cortisone only provides temporary relief, or you want regenerative healing over pain suppression.

Frequently Asked Questions

Can I get PRP after cortisone?
Yes, but wait 2-4 weeks. Cortisone suppresses the inflammation that PRP relies on.
How many cortisone injections can I have?
Most doctors limit cortisone to 3-4 injections per joint per year. Excessive cortisone weakens tendons and accelerates cartilage breakdown.
Is PRP more painful than cortisone?
The injections feel similar. PRP can cause 2-3 days of soreness afterward. Cortisone typically provides immediate relief.

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